C: Use with caution if benefits outweigh dangers. Animal scientific tests demonstrate possibility and human research not out there or neither animal nor human research performed.
pentobarbital will decrease the extent or impact of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is actually a delicate CYP3A4 substrate. Coadministration with potent or moderate CYP3A4 inducers is contraindicated.
pentobarbital will lower the extent or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
fentanyl transmucosal and pentobarbital both equally boost sedation. Stay away from or Use Alternate Drug. Limit use to individuals for whom choice treatment selections are inadequate
CYP3A4 inducers may well increase the formation from the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely check people taking ifosfamide with CYP3A4 inducers for toxicities and contemplate dose adjustment.
fentanyl intranasal and pentobarbital both boost sedation. Steer clear of or Use Alternate Drug. Limit use to people for whom different remedy choices are insufficient
benzhydrocodone/acetaminophen and pentobarbital equally maximize sedation. Stay clear of or Use Alternate Drug. Restrict use to sufferers for whom substitute remedy choices are here insufficient
The efficacy of hormonal contraceptives may very well be decreased. Use an alternative approach to contraception or possibly a backup approach when enzyme inducers are applied with combined hormonal contraceptives (CHCs), and continue backup contraception for 28 days right after discontinuing enzyme inducer to make certain contraceptive reliability.
buprenorphine, prolonged-acting injection and pentobarbital both of those raise sedation. Prevent or Use Alternate Drug. Limit use to people for whom substitute therapy solutions are insufficient
Aged or debilitated individuals might respond to barbiturates with marked melancholy, excitement, and confusion; in a few patients, barbiturates consistently generate excitement rather than despair
pentobarbital will decrease the level or outcome of alfentanil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unfamiliar.
pentobarbital will reduce the level or impact of buspirone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Coadministration of zuranolone with other CNS depressants may perhaps improve impairment of psychomotor effectiveness or CNS depressant effects. If unavoidable, take into account dose reduction. .
Keep an eye on Carefully (2)pentobarbital will decrease the extent or outcome of oliceridine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. If coadministration with a CYP3A4 inducer is essential, look at raising oliceridine dose until eventually steady drug effects are attained; keep track of for signs of opioid withdrawal.